AESKUCARE^® GRD

POINT-OF-CARE FOR CELIAC DISEASE AND GLUTEN-RELATED DISORDERS

Gluten-related disorders (GRDs) are a group of conditions that occur when the body reacts negatively to gluten, a protein found in foods such as wheat, barley, and rye. These conditions include celiac disease, non-celiac gluten sensitivity (NCGS), and wheat allergy. For many people, gluten consumption can lead to uncomfortable and sometimes serious symptoms such as stomach pain, bloating, headaches, fatigue, and joint pain.

Today, GRDs are becoming a growing health concern as more and more people are discovering that gluten may be the cause of their long-standing symptoms. If left undiagnosed, these conditions can lead to more serious problems such as malnutrition and chronic health issues. Early diagnosis is crucial, as it allows patients to take control of their health, make informed dietary changes, and stop suffering from unexplained symptoms.

The AESKUCARE^® Gluten Related Disorders IgA test is a comprehensive diagnostic tool that allows healthcare professionals to quickly and accurately detect and quantify specific IgA antibodies against multiple biomarkers linked to gluten-related disorders.

With the AESKUCARE^® GRD rapid test, healthcare professionals or laboratories can quickly offer advice (30 minutes) on symptom relief.

• The test kit includes all necessary equipment (test device, sample collection kit, reagents, etc.)
• Hygienic – the blood sample and reagents remain inside the device
• Suitable for both adults and children
• Designed to facilitate diagnosis and save time for healthcare professionals, diagnostic laboratories, nutritionists, dietitians, and patients.
• Only 50 μL of capillary blood is required
• Healthcare professionals and nutritionists can perform the test on patients during their visit, without waiting for laboratory results
• 18-month shelf life

AESKUCARE^® GRD delivers results with unmatched accuracy and speed!

WHY TAKE THE AESKUCARE® GRD TEST

The gold standard for celiac disease diagnosis

tTG (Tissue Ttransglutaminase) and tTG neo (tTG neo-epitopes)

tTG is a key marker in the diagnosis of celiac disease, as antibodies against tTG reflect the immune system's specific response to gluten. This marker is widely recognized as the gold standard for confirming celiac disease. The tTG neo variant improves this accuracy by detecting subtle immunological reactions, making it valuable for early and accurate diagnosis.

Addressing the challenges of the modern diet

mTG (microbial transglutaminase) and mTG neo (mTG neo-epitopes)

Microbial transglutaminase, commonly used in processed foods, shows significant enzymatic similarity to human tissue transglutaminase, a key diagnostic marker for celiac disease, particularly in its ability to cross-link protein structures. Antibodies against microbial transglutaminase and its protein complexes (mTG neo-epitopes) can be selectively detected in patients with GRD. Although mTG is not a conventional marker for celiac disease, ongoing research studies are demonstrating its important role in the early immune response in gluten-related disorders.

Focus on specific gluten reacrtions

DGP (deamidated gliadin peptides)

Deamidated gliadin peptides are modified fragments of gluten proteins that can trigger a specific immune response, making them a highly accurate marker for celiac disease. When the body produces antibodies against these modified gluten fragments, it indicates an active autoimmune response, which is crucial for diagnosing celiac disease and gluten-related disorders.

hidden Triggers in Wheat

Gliadin and Frazer fraction

Gliadin, a protein found in wheat gluten, plays a central role in triggering immune responses in individuals with gluten-related disorders, particularly celiac disease. The Frazer fraction refers to specific gliadin peptides identified as particularly immunogenic, meaning they are more likely to provoke an immune response.

Identifying the impact of gluten on skin health

TG3 (Transglutaminase 3)

Transglutaminase 3 is an enzyme found primarily in the skin and mucous membranes, playing a crucial role in stabilizing tissue structure. In the context of GRD, particularly celiac disease, TG3 serves as a valuable biomarker. In individuals with GRD, the immune system can produce antibodies targeting TG3, leading to inflammation and specific skin reactions. This immune response is most commonly observed in dermatitis herpetiformis, a characteristic skin manifestation of celiac disease.
 

How to perform the test

The rapid test is performed without the need for expensive equipment, as the kits contain everything needed to perform the analysis in just 30 minutes.

Furthermore, thanks to the dedicated free online portal, a professional report can be generated in just 3 minutes in various languages, making the test results easier to understand.